2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W011297S2
    Methyl arachidonate-13C4 2692624-39-6
    Methyl arachidonate-13C4 (Arachidonic acid methyl ester-13C4) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
    Methyl arachidonate-13C4
  • HY-W011297S3
    Methyl arachidonate-13C5
    Methyl arachidonate-13C5 (Arachidonic acid methyl ester-13C5) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
    Methyl arachidonate-13C5
  • HY-W011683S7
    2'-Deoxyadenosine monohydrate-15N5
    2'-Deoxyadenosine monohydrate-15N5 is the 15N labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-15N5
  • HY-W013049S2
    Docosanoic acid-d2 71607-34-6
    Docosanoic acid-d2 (Behenic acid-d2) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.
    Docosanoic acid-d2
  • HY-W014423S1
    L-Histidine-13C6,15N3,d5 hydrochloride hydrate 2483829-32-7
    L-Histidine-13C6,15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
    L-Histidine-13C6,15N3,d5 hydrochloride hydrate
  • HY-W014423S5
    L-Histidine-15N3 hydrochloride hydrate
    L-Histidine-15N3 (hydrochloride hydrate) is the 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
    L-Histidine-15N3 hydrochloride hydrate
  • HY-W015466S1
    Acetylvaline-13C2
    Acetylvaline-13C2 is the 13C-labeled Acetylvaline. Acetylvaline is an endogenous metabolite.
    Acetylvaline-13C2
  • HY-W015780S1
    1,4-Dimethoxybenzene-d4 21383-12-0
    1,4-Dimethoxybenzene-d4 is the deuterium labeled 1,4-Dimethoxybenzene (HY-W015780).1,4-Dimethoxybenzene is an endogenous metabolite.
    1,4-Dimethoxybenzene-d4
  • HY-W141978S1
    DL-Lysine-d8 dihydrochloride 284664-87-5
    DL-Lysine-d8 (dihydrochloride) is the deuterium labeled DL-Lysine[1].
    DL-Lysine-d8 dihydrochloride
  • HY-W013061S11
    Tripalmitin (Glycerol 13C3,13C 99%) 1246739-65-0
    Tripalmitin (Glycerol 13C3,13C 99%) is 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
    Tripalmitin (Glycerol 13C3,13C 99%)
  • HY-122666
    Org 25935 949588-40-3
    Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse.
    Org 25935
  • HY-127011
    7-Acetylintermedine 74243-01-9
    7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.
    7-Acetylintermedine
  • HY-B0682S
    Mitiglinide-d8 calcium hydrate
    Mitiglinide-d8 (calcium hydrate) (KAD-1229-d8) is the deuterium labeled Mitiglinide calcium hydrate. Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes[1][2].
    Mitiglinide-d8 calcium hydrate
  • HY-124208A
    L-770644 dihydrochloride 182251-68-9
    L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM).
    L-770644 dihydrochloride
  • HY-G0008AR
    O-Desmethyl Mebeverine alcohol (hydrochloride) (Standard) 856620-39-8
    Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments.
    O-Desmethyl Mebeverine alcohol (hydrochloride) (Standard)
  • HY-W014504R
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (Standard) 343-65-7
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (Standard) is the analytical standard of 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. This product is intended for research and analytical applications. 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (Standard)
  • HY-15267A
    (24R)-MC 976 112828-09-8
    (24R)-MC 976 is a Vitamin D3 derivative.
    (24R)-MC 976
  • HY-15267B
    (24S)-MC 976 112849-14-6
    (24S)-MC 976 is a Vitamin D3 derivative.
    (24S)-MC 976
  • HY-P0245
    Speract 76901-59-2
    Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
    Speract
  • HY-P0321
    Asp-Asp-Asp-Asp-Asp 124219-00-7
    Asp-Asp-Asp-Asp-Asp is a peptide consists of 5 Asp.
    Asp-Asp-Asp-Asp-Asp
Cat. No. Product Name / Synonyms Application Reactivity